hi,oh i remember this one, i am on 25mg inj mtx and i had no problems on tabs apart from a headache after taking the things,i was on 1 folic a week but when i went on inj sadly my lovely long long hair started to thin just a little at the front,i spoke to the rhumy nurse and was put on 6 folic a week and i got my hair cut just incase i lost alot,my hair has got a bit brittle and not as shiney as it used to be so yes i would say mtx has an effect on hair but then any meds have side effects we dont always notice them,i am not bothered about it really but the cut i have is now very meg ryan ie;wash and go look and is still in good condition my hair now has a mind of its own and being short it has gone curly,it does grow back takes a bit of time mind,i now have a normall hair loss,good luck,dorothy